Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoi...
Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity
About this item
Full title
Author / Creator
Liebmann, Marie , Hucke, Stephanie , Koch, Kathrin , Eschborn, Melanie , Ghelman, Julia , Chasan, Achmet I. , Glander, Shirin , Schädlich, Martin , Kuhlencord, Meike , Daber, Niklas M. , Eveslage, Maria , Beyer, Marc , Dietrich, Michael , Albrecht, Philipp , Stoll, Monika , Busch, Karin B. , Wiendl, Heinz , Roth, Johannes , Kuhlmann, Tanja and Klotz, Luisa
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
T cells critically depend on reprogramming of metabolic signatures to meet the bioenergetic demands during activation and clonal expansion. Here we identify the transcription factor Nur77 as a cell-intrinsic modulator of T cell activation. Nur77-deficient T cells are highly proliferative, and lack of Nur77 is associated with enhanced T cell activat...
Alternative Titles
Full title
Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity
Authors, Artists and Contributors
Author / Creator
Hucke, Stephanie
Koch, Kathrin
Eschborn, Melanie
Ghelman, Julia
Chasan, Achmet I.
Glander, Shirin
Schädlich, Martin
Kuhlencord, Meike
Daber, Niklas M.
Eveslage, Maria
Beyer, Marc
Dietrich, Michael
Albrecht, Philipp
Stoll, Monika
Busch, Karin B.
Wiendl, Heinz
Roth, Johannes
Kuhlmann, Tanja
Klotz, Luisa
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6112725
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6112725
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1721049115
