MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2
MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2
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Publisher
National Academy of Sciences
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Language
English
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Publisher
National Academy of Sciences
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Contents
The mitochondrial uniporter is a Ca2+-activated Ca2+ channel complex that displays exceptionally high conductance and selectivity. Here, we report cellular metal toxicity screens highlighting the uniporter’s role in Mn2+ toxicity. Cells lacking the pore-forming uniporter subunit, MCU, are more resistant to Mn2+ toxicity, while cells lacking the Ca2...
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Full title
MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6112746
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6112746
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1807811115
