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High‐affinity PD‐1 molecules deliver improved interaction with PD‐L1 and PD‐L2

High‐affinity PD‐1 molecules deliver improved interaction with PD‐L1 and PD‐L2

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6113430

High‐affinity PD‐1 molecules deliver improved interaction with PD‐L1 and PD‐L2

About this item

Full title

High‐affinity PD‐1 molecules deliver improved interaction with PD‐L1 and PD‐L2

Publisher

England: John Wiley & Sons, Inc

Journal title

Cancer science, 2018-08, Vol.109 (8), p.2435-2445

Language

English

Formats

Publication information

Publisher

England: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

The inhibitory checkpoint molecule programmed death (PD)‐1 plays a vital role in maintaining immune homeostasis upon binding to its ligands, PD‐L1 and PD‐L2. Several recent studies have demonstrated that soluble PD‐1 (sPD‐1) can block the interaction between membrane PD‐1 and PD‐L1 to enhance the antitumor capability of T cells. However, the affini...

Alternative Titles

Full title

High‐affinity PD‐1 molecules deliver improved interaction with PD‐L1 and PD‐L2

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6113430

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6113430

Other Identifiers

ISSN

1347-9032,1349-7006

E-ISSN

1349-7006

DOI

10.1111/cas.13666

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