RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-drive...
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers
About this item
Full title
Author / Creator
Nichols, Robert J. , Haderk, Franziska , Stahlhut, Carlos , Schulze, Christopher J. , Hemmati, Golzar , Wildes, David , Tzitzilonis, Christos , Mordec, Kasia , Marquez, Abby , Romero, Jason , Hsieh, Tientien , Zaman, Aubhishek , Olivas, Victor , McCoach, Caroline , Blakely, Collin M. , Wang, Zhengping , Kiss, Gert , Koltun, Elena S. , Gill, Adrian L. , Singh, Mallika , Goldsmith, Mark A. , Smith, Jacqueline A. M. and Bivona, Trever G.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAF
V600E
-driven cancers, effective targeted therapies are lacking for most cancers driven by other pathway alterations, including non-V600E oncogenic BRAF, RAS GTPase-activating protein...
Alternative Titles
Full title
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers
Authors, Artists and Contributors
Author / Creator
Haderk, Franziska
Stahlhut, Carlos
Schulze, Christopher J.
Hemmati, Golzar
Wildes, David
Tzitzilonis, Christos
Mordec, Kasia
Marquez, Abby
Romero, Jason
Hsieh, Tientien
Zaman, Aubhishek
Olivas, Victor
McCoach, Caroline
Blakely, Collin M.
Wang, Zhengping
Kiss, Gert
Koltun, Elena S.
Gill, Adrian L.
Singh, Mallika
Goldsmith, Mark A.
Smith, Jacqueline A. M.
Bivona, Trever G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6115280
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6115280
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-018-0169-1
