Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
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Publisher
United States: The American Association for the Advancement of Science
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Language
English
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United States: The American Association for the Advancement of Science
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Contents
Regulation by the integrated stress response (ISR) converges on the phosphorylation of translation initiation factor eIF2 in response to a variety of stresses. Phosphorylation converts eIF2 from a substrate to a competitive inhibitor of its dedicated guanine nucleotide exchange factor, eIF2B, thereby inhibiting translation. ISRIB, a drug-like eIF2B...
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Full title
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6120582
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6120582
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaq0939
