Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
About this item
Full title
Author / Creator
Cobo, Isidoro , Martinelli, Paola , Flández, Marta , Bakiri, Latifa , Zhang, Mingfeng , Carrillo-de-Santa-Pau, Enrique , Jia, Jinping , Sánchez-Arévalo Lobo, Víctor J. , Megías, Diego , Felipe, Irene , del Pozo, Natalia , Millán, Irene , Thommesen, Liv , Bruland, Torunn , Olson, Sara H. , Smith, Jill , Schoonjans, Kristina , Bamlet, William R. , Petersen, Gloria M. , Malats, Núria , Amundadottir, Laufey T. , Wagner, Erwin F. and Real, Francisco X.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
In mouse pancreas cells with only one copy of the
Nr5a2
gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an epithelial-cell-autonomous basal pre-inflammatory state.
Differentiation and inflammation networks overlap in the pancreas
Tissu...
Alternative Titles
Full title
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
Authors, Artists and Contributors
Author / Creator
Martinelli, Paola
Flández, Marta
Bakiri, Latifa
Zhang, Mingfeng
Carrillo-de-Santa-Pau, Enrique
Jia, Jinping
Sánchez-Arévalo Lobo, Víctor J.
Megías, Diego
Felipe, Irene
del Pozo, Natalia
Millán, Irene
Thommesen, Liv
Bruland, Torunn
Olson, Sara H.
Smith, Jill
Schoonjans, Kristina
Bamlet, William R.
Petersen, Gloria M.
Malats, Núria
Amundadottir, Laufey T.
Wagner, Erwin F.
Real, Francisco X.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6121728
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6121728
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature25751
