De novo NAD+ biosynthetic impairment in acute kidney injury in humans
De novo NAD+ biosynthetic impairment in acute kidney injury in humans
About this item
Full title
Author / Creator
Poyan Mehr, Ali , Tran, Mei T. , Ralto, Kenneth M. , Leaf, David E. , Washco, Vaughan , Messmer, Joseph , Lerner, Adam , Kher, Ajay , Kim, Steven H. , Khoury, Charbel C. , Herzig, Shoshana J. , Trovato, Mary E. , Simon-Tillaux, Noemie , Lynch, Matthew R. , Thadhani, Ravi I. , Clish, Clary B. , Khabbaz, Kamal R. , Rhee, Eugene P. , Waikar, Sushrut S. , Berg, Anders H. and Parikh, Samir M.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Nicotinamide adenine dinucleotide (NAD
+
) extends longevity in experimental organisms, raising interest in its impact on human health. De novo NAD
+
biosynthesis from tryptophan is evolutionarily conserved yet considered supplanted among higher species by biosynthesis from nicotinamide (NAM). Here we show that a bottleneck enzyme in de...
Alternative Titles
Full title
De novo NAD+ biosynthetic impairment in acute kidney injury in humans
Authors, Artists and Contributors
Author / Creator
Tran, Mei T.
Ralto, Kenneth M.
Leaf, David E.
Washco, Vaughan
Messmer, Joseph
Lerner, Adam
Kher, Ajay
Kim, Steven H.
Khoury, Charbel C.
Herzig, Shoshana J.
Trovato, Mary E.
Simon-Tillaux, Noemie
Lynch, Matthew R.
Thadhani, Ravi I.
Clish, Clary B.
Khabbaz, Kamal R.
Rhee, Eugene P.
Waikar, Sushrut S.
Berg, Anders H.
Parikh, Samir M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6129212
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6129212
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0138-z
