The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-dri...
The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The glucocorticoid receptor (GR) is a steroid hormone receptor of the nuclear receptor family that regulates gene expression in response to glucocorticoid hormone signaling. Interaction with specific GR DNA binding sequences causes conformational changes in the GR DNA binding domain (DBD) that result in recruitment of specific sets of co-regulators...
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The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6131172
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6131172
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-31812-9
