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A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6137806

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

About this item

Full title

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2017-11, Vol.551 (7681), p.517-520

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

An immune fitness model for tumours under checkpoint blockade immunotherapy is proposed, through which the authors show that the presentation and recognition properties of dominant neoantigens distributed over tumour subclones are predictive of response in melanoma and lung cancer cohorts.
Predicting tumour response to immunotherapy
Response...

Alternative Titles

Full title

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6137806

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6137806

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature24473

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