TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42
TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42
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Author / Creator
Xu, Song , Zhang, Yue , Wang, Jian , Li, Kai , Tan, Kang , Liang, Kangyan , Shen, Junhui , Cai, Daozhang , Jin, Dadi , Li, Mangmang , Xiao, Guozhi , Xu, Jiake , Jiang, Yu and Bai, Xiaochun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) functions centrally in OCLs to promote podosome organization and bone resorption through mechanistic target of rapamycin complex 1 (mTORC1) and the s...
Alternative Titles
Full title
TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6143527
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6143527
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-017-0049-4
