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TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs

TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6159955

TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs

About this item

Full title

TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4387-4396

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Activation of HIV-1 reservoirs and induction of anti-HIV-1 T cells are critical to control HIV-1 rebound after combined antiretroviral therapy (cART). Here we evaluated in humanized mice (hu-mice) with persistent HIV-1 infection the therapeutic effect of TLR3 agonist and a CD40-targeting HIV-1 vaccine, which consists of a string of 5 highly conserv...

Alternative Titles

Full title

TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6159955

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6159955

Other Identifiers

ISSN

0021-9738,1558-8238

E-ISSN

1558-8238

DOI

10.1172/JCI99005

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