Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new t...
Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option
About this item
Full title
Author / Creator
Stamm, Hauke , Klingler, Felix , Grossjohann, Eva-Maria , Muschhammer, Jana , Vettorazzi, Eik , Heuser, Michael , Mock, Ulrike , Thol, Felicitas , Vohwinkel, Gabi , Latuske, Emily , Bokemeyer, Carsten , Kischel, Roman , Dos Santos, Cedric , Stienen, Sabine , Friedrich, Matthias , Lutteropp, Michael , Nagorsen, Dirk , Wellbrock, Jasmin and Fiedler, Walter
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Immune checkpoints are promising targets in cancer therapy. Recently, poliovirus receptor (PVR) and poliovirus receptor-related 2 (PVRL2) have been identified as novel immune checkpoints. In this investigation we show that acute myeloid leukemia (AML) cell lines and AML patient samples highly express the T-cell immunoreceptor with Ig and ITIM domai...
Alternative Titles
Full title
Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option
Authors, Artists and Contributors
Author / Creator
Klingler, Felix
Grossjohann, Eva-Maria
Muschhammer, Jana
Vettorazzi, Eik
Heuser, Michael
Mock, Ulrike
Thol, Felicitas
Vohwinkel, Gabi
Latuske, Emily
Bokemeyer, Carsten
Kischel, Roman
Dos Santos, Cedric
Stienen, Sabine
Friedrich, Matthias
Lutteropp, Michael
Nagorsen, Dirk
Wellbrock, Jasmin
Fiedler, Walter
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6160395
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6160395
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0288-y
