Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
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Author / Creator
Mendoza, Pilar , Gruell, Henning , Nogueira, Lilian , Pai, Joy A. , Butler, Allison L. , Millard, Katrina , Lehmann, Clara , Suárez, Isabelle , Oliveira, Thiago Y. , Lorenzi, Julio C. C. , Cohen, Yehuda Z. , Wyen, Christoph , Kümmerle, Tim , Karagounis, Theodora , Lu, Ching-Lan , Handl, Lisa , Unson-O’Brien, Cecilia , Patel, Roshni , Ruping, Carola , Schlotz, Maike , Witmer-Pack, Maggi , Shimeliovich, Irina , Kremer, Gisela , Thomas, Eleonore , Seaton, Kelly E. , Horowitz, Jill , West, Anthony P. , Bjorkman, Pamela J. , Tomaras, Georgia D. , Gulick, Roy M. , Pfeifer, Nico , Fätkenheuer, Gerd , Seaman, Michael S. , Klein, Florian , Caskey, Marina and Nussenzweig, Michel C.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in which a combination of 3BNC117 and 10-1074, two potent monoclonal anti-HIV-1 broadly neutralizing antibodies that target independent sites on the HIV-1 envelope sp...
Alternative Titles
Full title
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Authors, Artists and Contributors
Author / Creator
Gruell, Henning
Nogueira, Lilian
Pai, Joy A.
Butler, Allison L.
Millard, Katrina
Lehmann, Clara
Suárez, Isabelle
Oliveira, Thiago Y.
Lorenzi, Julio C. C.
Cohen, Yehuda Z.
Wyen, Christoph
Kümmerle, Tim
Karagounis, Theodora
Lu, Ching-Lan
Handl, Lisa
Unson-O’Brien, Cecilia
Patel, Roshni
Ruping, Carola
Schlotz, Maike
Witmer-Pack, Maggi
Shimeliovich, Irina
Kremer, Gisela
Thomas, Eleonore
Seaton, Kelly E.
Horowitz, Jill
West, Anthony P.
Bjorkman, Pamela J.
Tomaras, Georgia D.
Gulick, Roy M.
Pfeifer, Nico
Fätkenheuer, Gerd
Seaman, Michael S.
Klein, Florian
Caskey, Marina
Nussenzweig, Michel C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6166473
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6166473
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0531-2
