Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
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Author / Creator
Liang, Yi-Lynn , Khoshouei, Maryam , Deganutti, Giuseppe , Glukhova, Alisa , Koole, Cassandra , Peat, Thomas S. , Radjainia, Mazdak , Plitzko, Jürgen M. , Baumeister, Wolfgang , Miller, Laurence J. , Hay, Deborah L. , Christopoulos, Arthur , Reynolds, Christopher A. , Wootten, Denise and Sexton, Patrick M.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin receptor-like receptor (CLR) class B G-protein-coupled receptor and a type 1 transmembrane domain protein, receptor activity-modifying protein 1 (RAMP1). Here we report th...
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Full title
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6166790
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6166790
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0535-y
