Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amp...
Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Despite the identification of
MYCN
amplification as an adverse prognostic marker in neuroblastoma, MYCN inhibitors have yet to be developed. Here, by integrating evidence from a whole-genome shRNA library screen and the computational inference of master regulator proteins, we identify transcription factor activating protein 4 (TFAP4) as a cri...
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Full title
Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6172192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6172192
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0326-9
