Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
About this item
Full title
Author / Creator
Reshef, Yakir A. , Finucane, Hilary K. , Kelley, David R. , Gusev, Alexander , Kotliar, Dylan , Ulirsch, Jacob C. , Hormozdiari, Farhad , Nasser, Joseph , O’Connor, Luke , van de Geijn, Bryce , Loh, Po-Ru , Grossman, Sharon R. , Bhatia, Gaurav , Gazal, Steven , Palamara, Pier Francesco , Pinello, Luca , Patterson, Nick , Adams, Ryan P. and Price, Alkes L
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Biological interpretation of genome-wide association study data frequently involves assessing whether SNPs linked to a biological process, for example, binding of a transcription factor, show unsigned enrichment for disease signal. However, signed annotations quantifying whether each SNP allele promotes or hinders the biological process can enable...
Alternative Titles
Full title
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Authors, Artists and Contributors
Author / Creator
Finucane, Hilary K.
Kelley, David R.
Gusev, Alexander
Kotliar, Dylan
Ulirsch, Jacob C.
Hormozdiari, Farhad
Nasser, Joseph
O’Connor, Luke
van de Geijn, Bryce
Loh, Po-Ru
Grossman, Sharon R.
Bhatia, Gaurav
Gazal, Steven
Palamara, Pier Francesco
Pinello, Luca
Patterson, Nick
Adams, Ryan P.
Price, Alkes L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202062
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202062
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0196-7
