Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis...
Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The epidermis is a self-renewal epithelium continuously exposed to the genotoxic effects of ultraviolet (UV) light, the main cause of skin cancer. Therefore, it needs robust self-protective mechanisms facing genomic damage. p53 has been shown to mediate apoptosis in sunburn cells of the epidermis. However, epidermal cells daily receive sublethal mu...
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Full title
Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202398
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202398
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-018-1130-8
