Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cel...
Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells
About this item
Full title
Author / Creator
Cordani, Marco , Butera, Giovanna , Dando, Ilaria , Torrens-Mas, Margalida , Butturini, Elena , Pacchiana, Raffaella , Oppici, Elisa , Cavallini, Chiara , Gasperini, Sara , Tamassia, Nicola , Nadal-Serrano, Mercedes , Coan, Michela , Rossi, Davide , Gaidano, Gianluca , Caraglia, Michele , Mariotto, Sofia , Spizzo, Riccardo , Roca, Pilar , Oliver, Jordi , Scupoli, Maria Teresa and Donadelli, Massimo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
The
TP53
tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy.
Methods
A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chronic lymphocytic l...
Alternative Titles
Full title
Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells
Authors, Artists and Contributors
Author / Creator
Butera, Giovanna
Dando, Ilaria
Torrens-Mas, Margalida
Butturini, Elena
Pacchiana, Raffaella
Oppici, Elisa
Cavallini, Chiara
Gasperini, Sara
Tamassia, Nicola
Nadal-Serrano, Mercedes
Coan, Michela
Rossi, Davide
Gaidano, Gianluca
Caraglia, Michele
Mariotto, Sofia
Spizzo, Riccardo
Roca, Pilar
Oliver, Jordi
Scupoli, Maria Teresa
Donadelli, Massimo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6203762
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6203762
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-018-0288-2
