Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
About this item
Full title
Author / Creator
Cheng, Chun-Ting , Qi, Yue , Wang, Yi-Chang , Chi, Kevin K. , Chung, Yiyin , Ouyang, Ching , Chen, Yun-Ru , Oh, Myung Eun , Sheng, Xiangpeng , Tang, Yulong , Liu, Yun-Ru , Lin, H. Helen , Kuo, Ching-Ying , Schones, Dustin , Vidal, Christina M. , Chu, Jenny C.-Y. , Wang, Hung-Jung , Chen, Yu-Han , Miller, Kyle M. , Chu, Peiguo , Yen, Yun , Jiang, Lei , Kung, Hsing-Jien and Ann, David K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Defective arginine synthesis, due to the silencing of
argininosuccinate synthase 1
(ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeutic strategies. Here we show that depletion...
Alternative Titles
Full title
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Authors, Artists and Contributors
Author / Creator
Qi, Yue
Wang, Yi-Chang
Chi, Kevin K.
Chung, Yiyin
Ouyang, Ching
Chen, Yun-Ru
Oh, Myung Eun
Sheng, Xiangpeng
Tang, Yulong
Liu, Yun-Ru
Lin, H. Helen
Kuo, Ching-Ying
Schones, Dustin
Vidal, Christina M.
Chu, Jenny C.-Y.
Wang, Hung-Jung
Chen, Yu-Han
Miller, Kyle M.
Chu, Peiguo
Yen, Yun
Jiang, Lei
Kung, Hsing-Jien
Ann, David K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6203837
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6203837
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-018-0178-4
