Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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MDM2 mutations that prevent E2–ubiquitin binding without altering RING domain structure lead to loss of E3-ligase activity, while the ability to limit p53 transcriptional activity is retained, allowing cells to respond more quickly to cellular stress.
MDM2–MDMX complexes bind the p53 tumor-suppressor protein, inhibiting p53's transcriptional act...
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Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6205632
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6205632
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3414
