Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2−/− m...
Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2−/− mice and human primary sclerosing cholangitis
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Publisher
New York: Elsevier Inc
Journal title
Language
English
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Publisher
New York: Elsevier Inc
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Scope and Contents
Contents
Ursodeoxycholic acid (UDCA) is used to treat biliary disorders; and, bile acids alter mast cell (MC) histamine release. MCs infiltrate Mdr2−/− mice liver (model of primary sclerosing cholangitis (PSC)). MC-derived histamine increases inflammation, hepatic stellate cell (HSC) activation and fibrosis. The objective was to determine the effects of UDC...
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Full title
Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2−/− mice and human primary sclerosing cholangitis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6214746
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6214746
Other Identifiers
ISSN
0023-6837
E-ISSN
1530-0307
DOI
10.1038/s41374-018-0101-0
