Promoter-bound METTL3 maintains myeloid leukaemia via m6A-dependent translation control
Promoter-bound METTL3 maintains myeloid leukaemia via m6A-dependent translation control
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Author / Creator
Barbieri, Isaia , Tzelepis, Konstantinos , Pandolfini, Luca , Shi, Junwei , Millán-Zambrano, Gonzalo , Robson, Samuel C. , Aspris, Demetrios , Migliori, Valentina , Bannister, Andrew J. , Han, Namshik , De Braekeleer, Etienne , Ponstingl, Hannes , Hendrick, Alan , Vakoc, Christopher R. , Vassiliou, George S. and Kouzarides, Tony
Journal title
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English
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Contents
N6-methyladenosine (m6A) is an abundant internal RNA modification in both coding
1
and non-coding RNAs
2
,
3
, catalysed by the METTL3/METTL14 methyltransferase complex
4
. Here we define a novel pathway specific for METTL3, implicated in the maintenance of the leukaemic state. We identify
METTL3
as an essential gene f...
Alternative Titles
Full title
Promoter-bound METTL3 maintains myeloid leukaemia via m6A-dependent translation control
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6217924
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6217924
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature24678
