Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling ax...
Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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It remains unclear whether PAX6 acts as a crucial transcription factor for lung cancer stem cell (CSC) traits. We demonstrate that PAX6 acts as an oncogene responsible for induction of cancer stemness properties in lung adenocarcinoma (LUAD). Mechanistically, PAX6 promotes GLI transcription, resulting in SOX2 upregulation directly by the binding of...
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Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6226336
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6226336
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0373-2
