Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded...
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cyclosporine, a widely used immunosuppressant in organ transplantation and in treatment of various autoimmune diseases, activates the unfolded protein response (UPR), an ER stress coping response. In this study we discovered a new and unanticipated cyclosporine-dependent signaling pathway, with cyclosporine triggering direct activation of the UPR....
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Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6232179
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6232179
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-34891-w
