Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cell models of mitochondrial complex I (CI) deficiency display activation of glycolysis to compensate for the loss in mitochondrial ATP production. This adaptation can mask other relevant deficiency-induced aberrations in cell physiology. Here we investigated the viability, mitochondrial morphofunction, ROS levels and ATP homeostasis of primary ski...
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Full title
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6235972
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6235972
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-018-1179-4
