Genetically engineered human cortical spheroid models of tuberous sclerosis
Genetically engineered human cortical spheroid models of tuberous sclerosis
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Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by mutations in the
TSC1
or
TSC2
genes, whose protein products are negative regulators of mechanistic target of rapamycin complex 1 signaling. Hallmark pathologies of TSC are cortical tubers—regions of dysmorphic, disorganized neurons and glia in the cortex...
Alternative Titles
Full title
Genetically engineered human cortical spheroid models of tuberous sclerosis
Authors, Artists and Contributors
Author / Creator
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6261470
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6261470
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0139-y
