Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12
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mice display PHARC-like phenotypes, including hearing loss, along with elevated brain lyso-PS and features of stimulated innate immune cell function. Here, we de...
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Full title
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6263940
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6263940
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-018-0155-8
