Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
About this item
Full title
Author / Creator
Hodgson, Darren R. , Dougherty, Brian A. , Lai, Zhongwu , Fielding, Anitra , Grinsted, Lynda , Spencer, Stuart , O’Connor, Mark J. , Ho, Tony W. , Robertson, Jane D. , Lanchbury, Jerry S. , Timms, Kirsten M. , Gutin, Alexander , Orr, Maria , Jones, Helen , Gilks, Blake , Womack, Chris , Gourley, Charlie , Ledermann, Jonathan and Barrett, J. Carl
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
Olaparib (Lynparza™) is a PARP inhibitor approved for advanced
BRCA
-mutated (
BRCA
m) ovarian cancer. PARP inhibitors may benefit patients whose tumours are dysfunctional in DNA repair mechanisms unrelated to
BRCA1/2
. We report exploratory analyses, including the long-term outcome of candidate biomarkers of sensiti...
Alternative Titles
Full title
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
Authors, Artists and Contributors
Author / Creator
Dougherty, Brian A.
Lai, Zhongwu
Fielding, Anitra
Grinsted, Lynda
Spencer, Stuart
O’Connor, Mark J.
Ho, Tony W.
Robertson, Jane D.
Lanchbury, Jerry S.
Timms, Kirsten M.
Gutin, Alexander
Orr, Maria
Jones, Helen
Gilks, Blake
Womack, Chris
Gourley, Charlie
Ledermann, Jonathan
Barrett, J. Carl
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6265286
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6265286
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-018-0274-8
