L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions
L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions
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Publisher
United States: Oxford University Press
Journal title
Language
English
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Publisher
United States: Oxford University Press
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Scope and Contents
Contents
Background. Sofosbuvir (SOF) exhibits a high barrier to resistance, with no S282T NS5B substitution or phenotypic resistance detected in phase 3 registration studies. Methods. Here, emergence of the NS5B variants L159F and V321A and possible association with resistance was evaluated in 8 studies of SOF (NEUTRINO, FISSION, POSITRON, FUSION, VALENCE,...
Alternative Titles
Full title
L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6281391
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6281391
Other Identifiers
ISSN
0022-1899
E-ISSN
1537-6613
DOI
10.1093/infdis/jiv564
