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Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6305802

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

About this item

Full title

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Publisher

United States: Elsevier Inc

Journal title

Molecular therapy. Methods & clinical development, 2019-06, Vol.13, p.14-26

Language

English

Formats

Publication information

Publisher

United States: Elsevier Inc

More information

Scope and Contents

Contents

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors. Here, we set up a scalable process for AAV production, using orbitally shaken bioreactors and...

Alternative Titles

Full title

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6305802

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6305802

Other Identifiers

ISSN

2329-0501

E-ISSN

2329-0501

DOI

10.1016/j.omtm.2018.11.004

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