Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
About this item
Full title
Author / Creator
Lucifora, Julie , Xia, Yuchen , Reisinger, Florian , Zhang, Ke , Stadler, Daniela , Cheng, Xiaoming , Sprinzl, Martin F. , Koppensteiner, Herwig , Makowska, Zuzanna , Volz, Tassilo , Remouchamps, Caroline , Chou, Wen-Min , Thasler, Wolfgang E. , Hüser, Norbert , Durantel, David , Liang, T. Jake , Münk, Carsten , Heim, Markus H. , Browning, Jeffrey L. , Dejardin, Emmanuel , Dandri, Maura , Schindler, Michael , Heikenwalder, Mathias and Protzer, Ulrike
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment can clear HBV but is limited by systemic side effects. We describe how interferon-α can induce specific degradation of the nuclear viral DNA without hepatotoxicity a...
Alternative Titles
Full title
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
Authors, Artists and Contributors
Author / Creator
Xia, Yuchen
Reisinger, Florian
Zhang, Ke
Stadler, Daniela
Cheng, Xiaoming
Sprinzl, Martin F.
Koppensteiner, Herwig
Makowska, Zuzanna
Volz, Tassilo
Remouchamps, Caroline
Chou, Wen-Min
Thasler, Wolfgang E.
Hüser, Norbert
Durantel, David
Liang, T. Jake
Münk, Carsten
Heim, Markus H.
Browning, Jeffrey L.
Dejardin, Emmanuel
Dandri, Maura
Schindler, Michael
Heikenwalder, Mathias
Protzer, Ulrike
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6309542
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6309542
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1243462
