Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The emergence of primordial RNA-based life would have required the abiotic synthesis of nucleotides, and their participation in nonenzymatic RNA replication. Although considerable progress has been made toward potentially prebiotic syntheses of the pyrimidine nucleotides (C and U) and their 2-thio variants, efficient routes to the canonical purine...
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Full title
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6310819
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6310819
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1814367115
