Structure of the µ-opioid receptor–Gi protein complex
Structure of the µ-opioid receptor–Gi protein complex
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Author / Creator
Koehl, Antoine , Hu, Hongli , Maeda, Shoji , Zhang, Yan , Qu, Qianhui , Paggi, Joseph M. , Latorraca, Naomi R. , Hilger, Daniel , Dawson, Roger , Matile, Hugues , Schertler, Gebhard F. X. , Granier, Sebastien , Weis, William I. , Dror, Ron O. , Manglik, Aashish , Skiniotis, Georgios and Kobilka, Brian K.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most clinically and recreationally used opioids. The induced positive effects of analgesia and euphoria are mediated by μOR signalling through the adenylyl cyclase-inhibiting heterotrimeric G protein G
i
. Here we present the 3.5 Å resolution cryo-electron mi...
Alternative Titles
Full title
Structure of the µ-opioid receptor–Gi protein complex
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6317904
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6317904
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0219-7
