The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/...
The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation
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Author / Creator
He, Jun , Gao, Hao-xue , Yang, Na , Zhu, Xiao-dong , Sun, Run-bin , Xie, Yuan , Zeng, Cai-hong , Zhang, Jing-wei , Wang, Jian-kun , Ding, Fei , Aa, Ji-ye and Wang, Guang-ji
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically. Our pilot experiments and accumulated evidences showed that epalrestat inhibited polyol pathway and reduced sorbitol production, and suggested the potential renal protection effects of epalrestat on diabetic nephrop...
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Full title
The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6318276
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6318276
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/s41401-018-0043-5
