Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells thro...
Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D
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Author / Creator
Hu, Peishan , Li, Shanshan , Tian, Ningyu , Wu, Fan , Hu, Yan , Li, Dengke , Qi, Yingjiao , Wei, Zhizhong , Wei, Qunfang , Li, Yanchao , Yin, Bin , Jiang, Tao , Yuan, Jiangang , Qiang, Boqin , Han, Wei and Peng, Xiaozhong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Acidosis is a significant feature of the tumor microenvironment in glioma, and it is closely related to multiple biological functions of cancer stem cells. Here, we found that the self-renewal ability, the mitochondrial activity and ATP production were elevated in stem cell-like glioma cells (SLCs) under acidic microenvironment, which promoted and...
Alternative Titles
Full title
Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6328565
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6328565
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-018-1242-1
