Minimal functional driver gene heterogeneity among untreated metastases
Minimal functional driver gene heterogeneity among untreated metastases
About this item
Full title
Author / Creator
Reiter, Johannes G , Makohon-Moore, Alvin P , Gerold, Jeffrey M , Heyde, Alexander , Attiyeh, Marc A , Kohutek, Zachary A , Tokheim, Collin J , Brown, Alexia , DeBlasio, Rayne M , Niyazov, Juliana , Zucker, Amanda , Karchin, Rachel , Kinzler, Kenneth W , Iacobuzio-Donahue, Christine A , Vogelstein, Bert and Nowak, Martin A
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: The American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Metastases are responsible for the majority of cancer-related deaths. Although genomic heterogeneity within primary tumors is associated with relapse, heterogeneity among treatment-naïve metastases has not been comprehensively assessed. We analyzed sequencing data for 76 untreated metastases from 20 patients and inferred cancer phylogenies for brea...
Alternative Titles
Full title
Minimal functional driver gene heterogeneity among untreated metastases
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6329287
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6329287
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aat7171
