Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
About this item
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Author / Creator
Mezzadra, Riccardo , Sun, Chong , Jae, Lucas T. , Gomez-Eerland, Raquel , de Vries, Evert , Wu, Wei , Logtenberg, Meike E. W. , Slagter, Maarten , Rozeman, Elisa A. , Hofland, Ingrid , Broeks, Annegien , Horlings, Hugo M. , Wessels, Lodewyk F. A. , Blank, Christian U. , Xiao, Yanling , Heck, Albert J. R. , Borst, Jannie , Brummelkamp, Thijn R. and Schumacher, Ton N. M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells.
Regulating immunity evasion
PD-1/PD-L1 blocking antibodies are effective in the treatment of various cancers. In this study, Ton Schumacher and colleagues describe a haploid genetic screen to identify...
Alternative Titles
Full title
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
Authors, Artists and Contributors
Author / Creator
Sun, Chong
Jae, Lucas T.
Gomez-Eerland, Raquel
de Vries, Evert
Wu, Wei
Logtenberg, Meike E. W.
Slagter, Maarten
Rozeman, Elisa A.
Hofland, Ingrid
Broeks, Annegien
Horlings, Hugo M.
Wessels, Lodewyk F. A.
Blank, Christian U.
Xiao, Yanling
Heck, Albert J. R.
Borst, Jannie
Brummelkamp, Thijn R.
Schumacher, Ton N. M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6333292
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6333292
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature23669
