Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injur...
Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
About this item
Full title
Author / Creator
Bodo, Sahra , Campagne, Cécile , Thin, Tin Htwe , Higginson, Daniel S. , Vargas, H. Alberto , Hua, Guoqiang , Fuller, John D. , Ackerstaff, Ellen , Russell, James , Zhang, Zhigang , Klingler, Stefan , Cho, HyungJoon , Kaag, Matthew G. , Mazaheri, Yousef , Rimner, Andreas , Manova-Todorova, Katia , Epel, Boris , Zatcky, Joan , Cleary, Cristian R. , Rao, Shyam S. , Yamada, Yoshiya , Zelefsky, Michael J. , Halpern, Howard J. , Koutcher, Jason A. , Cordon-Cardo, Carlos , Greco, Carlo , Haimovitz-Friedman, Adriana , Sala, Evis , Powell, Simon N. , Kolesnick, Richard and Fuks, Zvi
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Tumor cure with conventional fractionated radiotherapy is 65%, dependent on tumor cell-autonomous gradual buildup of DNA double-strand break (DSB) misrepair. Here we report that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human cancers, operates a distinct dual-target mechanism, linking acid sphingomyelinas...
Alternative Titles
Full title
Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
Authors, Artists and Contributors
Author / Creator
Campagne, Cécile
Thin, Tin Htwe
Higginson, Daniel S.
Vargas, H. Alberto
Hua, Guoqiang
Fuller, John D.
Ackerstaff, Ellen
Russell, James
Zhang, Zhigang
Klingler, Stefan
Cho, HyungJoon
Kaag, Matthew G.
Mazaheri, Yousef
Rimner, Andreas
Manova-Todorova, Katia
Epel, Boris
Zatcky, Joan
Cleary, Cristian R.
Rao, Shyam S.
Yamada, Yoshiya
Zelefsky, Michael J.
Halpern, Howard J.
Koutcher, Jason A.
Cordon-Cardo, Carlos
Greco, Carlo
Haimovitz-Friedman, Adriana
Sala, Evis
Powell, Simon N.
Kolesnick, Richard
Fuks, Zvi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6355243
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6355243
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI97631
