Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
About this item
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Author / Creator
Cheng, Zhuo , He, Zhiying , Cai, Yongchao , Zhang, Cheng , Fu, Gongbo , Li, Hengyu , Sun, Wen , Liu, Changcheng , Cui, Xiuliang , Ning, Beifang , Xiang, Daimin , Zhou, Tengfei , Li, Xiaofeng , Xie, Weifen , Wang, Hongyang and Ding, Jin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Normal cells become cancer cells after a malignant transformation, but whether cancer cells can be reversed to normal status remains elusive. Here, we report that the combination of hepatocyte nuclear factor 1A (HNF1A), HNF4A and forkhead box protein A3 (FOXA3) synergistically reprograms hepatocellular carcinoma (HCC) cells to hepatocyte-like cells...
Alternative Titles
Full title
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6355772
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6355772
Other Identifiers
ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/s41422-018-0111-x
