An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
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Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Small molecules containing the
N
-nitroso group, such as the bacterial natural product streptozotocin, are prominent carcinogens
1
,
2
and important cancer chemotherapeutics
3
,
4
. Despite the considerable importance of this functional group to human health, enzymes dedicated to the assembly of the
N
-nitroso un...
Alternative Titles
Full title
An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6369591
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6369591
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-019-0894-z
