Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex c...
Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules
About this item
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to increase antibody responses, but the underlying mechanism has been unclear. We have here investigated the GC reaction after targeting antigen to MHCII in (i) a defined model with T and B cells o...
Alternative Titles
Full title
Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6370881
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6370881
Other Identifiers
ISSN
2059-0105
E-ISSN
2059-0105
DOI
10.1038/s41541-019-0101-0
