T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability
T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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T cell receptor cross-reactivity allows a fixed T cell repertoire to respond to a much larger universe of potential antigens. Recent work has emphasized the importance of peptide structural and chemical homology, as opposed to sequence similarity, in T cell receptor cross-reactivity. Surprisingly, though, T cell receptors can also cross-react betwe...
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T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6371774
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6371774
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-018-0130-4