AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Aberrant activation of AKT disturbs the proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand the upstream signalling pathways governing AKT activation. Here, we report that AKT undergoes SETDB1-mediated lysine methylation to promote its activation, which is antagonized by the Jumonji-family...
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Full title
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6377565
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6377565
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-018-0261-6
