Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulat...
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
About this item
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Author / Creator
Durbin, Adam D. , Zimmerman, Mark W. , Dharia, Neekesh V. , Abraham, Brian J. , Iniguez, Amanda Balboni , Weichert-Leahey, Nina , He, Shuning , Krill-Burger, John M. , Root, David E. , Vazquez, Francisca , Tsherniak, Aviad , Hahn, William C. , Golub, Todd R. , Young, Richard A. , Look, A. Thomas and Stegmaier, Kimberly
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Childhood high-risk neuroblastomas with
MYCN
gene amplification are difficult to treat effectively
1
. This has focused attention on tumor-specific gene dependencies that underlie tumorigenesis and thus provide valuable targets for the development of novel therapeutics. Using unbiased genome-scale CRISPR–Cas9 approaches to detect genes...
Alternative Titles
Full title
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6386470
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6386470
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0191-z
