CD4 receptor diversity in chimpanzees protects against SIV infection
CD4 receptor diversity in chimpanzees protects against SIV infection
About this item
Full title
Author / Creator
Bibollet-Ruche, Frederic , Russell, Ronnie M. , Liu, Weimin , Stewart-Jones, Guillaume B. E. , Sherrill-Mix, Scott , Li, Yingying , Learn, Gerald H. , Smith, Andrew G. , Gondim, Marcos V. P. , Plenderleith, Lindsey J. , Decker, Julie M. , Easlick, Juliet L. , Wetzel, Katherine S. , Collman, Ronald G. , Ding, Shilei , Finzi, Andrés , Ayouba, Ahidjo , Peeters, Martine , Leendertz, Fabian H. , van Schijndel, Joost , Goedmakers, Annemarie , Ton, Els , Boesch, Christophe , Kuehl, Hjalmar , Arandjelovic, Mimi , Dieguez, Paula , Murai, Mizuki , Colin, Christelle , Koops, Kathelijne , Speede, Sheri , Gonder, Mary K. , Muller, Martin N. , Sanz, Crickette M. , Morgan, David B. , Atencia, Rebecca , Cox, Debby , Piel, Alex K. , Stewart, Fiona A. , Ndjango, Jean-Bosco N. , Mjungu, Deus , Lonsdorf, Elizabeth V. , Pusey, Anne E. , Kwong, Peter D. , Sharp, Paul M. , Shaw, George M. and Hahn, Beatrice H.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Human and simian immunodeficiency viruses (HIV/SIVs) use CD4 as the primary receptor to enter target cells. Here, we show that the chimpanzee CD4 is highly polymorphic, with nine coding variants present in wild populations, and that this diversity interferes with SIV envelope (Env)–CD4 interactions. Testing the replication fitness of SIVcpz strains...
Alternative Titles
Full title
CD4 receptor diversity in chimpanzees protects against SIV infection
Authors, Artists and Contributors
Author / Creator
Russell, Ronnie M.
Liu, Weimin
Stewart-Jones, Guillaume B. E.
Sherrill-Mix, Scott
Li, Yingying
Learn, Gerald H.
Smith, Andrew G.
Gondim, Marcos V. P.
Plenderleith, Lindsey J.
Decker, Julie M.
Easlick, Juliet L.
Wetzel, Katherine S.
Collman, Ronald G.
Ding, Shilei
Finzi, Andrés
Ayouba, Ahidjo
Peeters, Martine
Leendertz, Fabian H.
van Schijndel, Joost
Goedmakers, Annemarie
Ton, Els
Boesch, Christophe
Kuehl, Hjalmar
Arandjelovic, Mimi
Dieguez, Paula
Murai, Mizuki
Colin, Christelle
Koops, Kathelijne
Speede, Sheri
Gonder, Mary K.
Muller, Martin N.
Sanz, Crickette M.
Morgan, David B.
Atencia, Rebecca
Cox, Debby
Piel, Alex K.
Stewart, Fiona A.
Ndjango, Jean-Bosco N.
Mjungu, Deus
Lonsdorf, Elizabeth V.
Pusey, Anne E.
Kwong, Peter D.
Sharp, Paul M.
Shaw, George M.
Hahn, Beatrice H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6386711
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6386711
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1821197116
