Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice
Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins. Thus, aHUS provides an archetypal complement-mediated disease with which to model new therapeutic strategies and treatments. Herein, we show t...
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Full title
Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6391106
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6391106
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI99296
