Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mecha...
Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The mitochondrial uniporter is a Ca2+-channel complex resident within the organelle’s inner membrane. In mammalian cells the uniporter’s activity is regulated by Ca2+ due to concerted action of MICU1 and MICU2, two paralogous, but functionally distinct, EF-hand Ca2+-binding proteins. Here we present the X-ray structure of the apo form of Mus muscul...
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Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6397551
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6397551
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1817759116
