Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal t...
Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)
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Author / Creator
Heinrich, Michael C. , Patterson, Janice , Beadling, Carol , Wang, Yuexiang , Debiec-Rychter, Maria , Dewaele, Barbara , Corless, Christopher L. , Duensing, Anette , Raut, Chandrajit P. , Rubin, Brian , Ordog, Tamas , van de Rijn, Matt , Call, Jerry , Mühlenberg, Thomas , Fletcher, Jonathan A. and Bauer, Sebastian
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Activating mutations of the receptor tyrosine kinase
are early events in the development of most gastrointestinal stromal tumors (GISTs). Although GISTs generally remain dependent on oncogenic
during tumor progression,
mutations alone are insufficient to induce malignant behavior. This is evidenced by
-mutant micro-GISTs, which are pres...
Alternative Titles
Full title
Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6399846
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6399846
Other Identifiers
ISSN
2045-3329
E-ISSN
2045-3329
DOI
10.1186/s13569-019-0112-7
