A homing system targets therapeutic T cells to brain cancer
A homing system targets therapeutic T cells to brain cancer
About this item
Full title
Author / Creator
Samaha, Heba , Pignata, Antonella , Fousek, Kristen , Ren, Jun , Lam, Fong W. , Stossi, Fabio , Dubrulle, Julien , Salsman, Vita S. , Krishnan, Shanmugarajan , Hong, Sung-Ha , Baker, Matthew L. , Shree, Ankita , Gad, Ahmed Z. , Shum, Thomas , Fukumura, Dai , Byrd, Tiara T. , Mukherjee, Malini , Marrelli, Sean P. , Orange, Jordan S. , Joseph, Sujith K. , Sorensen, Poul H. , Taylor, Michael D. , Hegde, Meenakshi , Mamonkin, Maksim , Jain, Rakesh K. , El-Naggar, Shahenda and Ahmed, Nabil
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Successful T cell immunotherapy for brain cancer requires that the T cells can access tumour tissues, but this has been difficult to achieve. Here we show that, in contrast to inflammatory brain diseases such as multiple sclerosis, where endothelial cells upregulate ICAM1 and VCAM1 to guide the extravasation of pro-inflammatory cells, cancer endoth...
Alternative Titles
Full title
A homing system targets therapeutic T cells to brain cancer
Authors, Artists and Contributors
Author / Creator
Pignata, Antonella
Fousek, Kristen
Ren, Jun
Lam, Fong W.
Stossi, Fabio
Dubrulle, Julien
Salsman, Vita S.
Krishnan, Shanmugarajan
Hong, Sung-Ha
Baker, Matthew L.
Shree, Ankita
Gad, Ahmed Z.
Shum, Thomas
Fukumura, Dai
Byrd, Tiara T.
Mukherjee, Malini
Marrelli, Sean P.
Orange, Jordan S.
Joseph, Sujith K.
Sorensen, Poul H.
Taylor, Michael D.
Hegde, Meenakshi
Mamonkin, Maksim
Jain, Rakesh K.
El-Naggar, Shahenda
Ahmed, Nabil
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6402337
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6402337
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0499-y
