Acarbose improves health and lifespan in aging HET3 mice
Acarbose improves health and lifespan in aging HET3 mice
About this item
Full title
Author / Creator
Harrison, David E. , Strong, Randy , Alavez, Silvestre , Astle, Clinton Michael , DiGiovanni, John , Fernandez, Elizabeth , Flurkey, Kevin , Garratt, Michael , Gelfond, Jonathan A. L. , Javors, Martin A. , Levi, Moshe , Lithgow, Gordon J. , Macchiarini, Francesca , Nelson, James F. , Sukoff Rizzo, Stacey J. , Slaga, Thomas J. , Stearns, Tim , Wilkinson, John Erby and Miller, Richard A.
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
England: John Wiley & Sons, Inc
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More information
Scope and Contents
Contents
To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three sites. Each dose led to a significant change (by log‐rank test) in both sexes, with larger effe...
Alternative Titles
Full title
Acarbose improves health and lifespan in aging HET3 mice
Authors, Artists and Contributors
Author / Creator
Strong, Randy
Alavez, Silvestre
Astle, Clinton Michael
DiGiovanni, John
Fernandez, Elizabeth
Flurkey, Kevin
Garratt, Michael
Gelfond, Jonathan A. L.
Javors, Martin A.
Levi, Moshe
Lithgow, Gordon J.
Macchiarini, Francesca
Nelson, James F.
Sukoff Rizzo, Stacey J.
Slaga, Thomas J.
Stearns, Tim
Wilkinson, John Erby
Miller, Richard A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6413665
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6413665
Other Identifiers
ISSN
1474-9718,1474-9726
E-ISSN
1474-9726
DOI
10.1111/acel.12898
